stiri medicale

[originaltup]

incep cu o chestie care mi se pare interesanta:

Efficacy and Safety of Inhaled Insulin (Exubera) Compared With Subcutaneous Insulin Therapy in Patients With Type 1 Diabetes

- in mare ei zic ca metodele sunt comparabile ca eficacitate, cu un plus pt forma inhalata cand vine vorba de satisfactia pacientului. Ar reprezenta o schimbare destul de mare, nu credeti?

http://www.medscape.com/viewarticle/493211

[A CERB]

singurul comentariu ar fi ca pe astia ii mananca-n kur. ar fi fost mai logic sa incerce intai cu type 2( mai putin fragili) si mai numerosi. parerea mea.

daca intr-adevar merge, e o treaba buna, evident.

[originaltup]

au mai fost inainte studii mai mici, si cu tip1 si cu tip2, asta e insa mai mare si randomizat.
Si ideea e ca asta inhalata e in loc de injectia de dinainte de masa, care se combina cu single bedtime long-acting insulin. Deci tot raman cu o injectie pe zi, dar mai bine doar una in loc de 3-5.

[A CERB]

eu nu am decat doi diabetici tip 1 in practica( aici toata lumea ii trimte la endo, din cauza de liability). in schimb, am cateva sute de diabetici tip 2, o buna parte pe insulina. experienta mea cu glargine( LANTUS) plus rapid acting( lispro, aspart) este destul de disappointing. majoritatea o duc foarte bine pe Novolog 73/30 doua injectii pe zi( care vin intr-un stilou cu ace de 30). daca aia de tip 1 sunt asa de fragili, in general ajung la pompa.

again, sunt curios sa vad cam cu ce se mananca, dar e prea devreme sa punem cruce injectiilor.

[plure]

Nu stiu daca poate fi considerata stire medicala ceea ce vezi pe Hotmail langa Inbox, dar...

http://content.health.msn.com/content/article/97/104268.htm
Human Test: Novel Vaccine Stops HIV
Treatment Turns On Anti-HIV Immunity, Holds AIDS Virus in Check

By  Daniel DeNoon  


Reviewed By Charlotte Grayson, MD
on Monday, November 29, 2004
WebMD Medical News



Nov. 29, 2004 -- It worked in mice. It worked in monkeys. And now in humans, a therapeutic vaccine has stopped HIV in its tracks.

The vaccine is made from a patient's own dendritic cells and HIV isolated from the patient's own blood. Dendritic cells are crucial to the immune response. They grab foreign bodies in the blood and present them to other immune cells to trigger powerful immune system responses to destroy the foreign invaders.

HIV infection normally turns these important immune system responses off. But animal studies show that when dendritic cells are "loaded" with whole, killed AIDS viruses, they can trigger effective immune responses that keep infected animals from dying of AIDS.

Wei Lu, Jean-Marie Andrieu, and colleagues at the University of Paris in France and Pernambuco Federal University in Recife, Brazil, tested the vaccine on 18 Brazilian patients. All had HIV infection for at least a year. Their T-cell counts -- a crucial measure of AIDS progression -- were dropping, meaning their disease was worsening. None was taking anti-HIV medications.

After getting three under-the-skin injections of the tailor-made vaccine, the amount of HIV in the patients' blood (called the viral load) dropped by 80%. After a year, eight of the 18 patients still had a 90% drop in HIV levels. All patients' T-cell counts stopped dropping.

The findings appear in the December issue of Nature Medicine.

"The results suggest that [these] vaccines could be a promising strategy for treating people with chronic HIV infection," Andrieu and colleagues write. "The significant decrease of viral load as well as maintenance of ... [T-]cell counts observed at one year after immunization are particularly promising."

The researchers warn that their study is only proof of principle. It's still not clear which patients do best with the vaccine, although there's evidence that vaccination should be given as soon after HIV infection as possible. Only clinical trials comparing people who get the vaccine to those who don't can show whether this vaccine really is an effective AIDS therapy.

Similar approaches are being explored for the treatment of cancer and long-term viral infections such as hepatitis C.


--------------------------------------------------------------------------------

SOURCE: Lu, W. Nature Medicine, December 2004, advance online publication.

[Furnika]

O noua idee despre cancer, in Science:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15567866
E si un moldovean printre autori. Daca vreti articolul full, pm me.

[originaltup]

It worked in mice.

nu mai stiu exact, dar parca HIV infecta doar oamenii ?!

[Furnika]

Probabil au facut un soarece uman.:lol: Sau knockin cu CD4 ca model, desi nu am auzit. Who knows?

[originaltup]

O sa mai postez pe aici news sau review-uri peste care dau prin medscape si care mi se par interesante, nu de alta dar poate mai sunt si altii ca mine care intra mult mai mult pe forum decat pe alte site-uri  :D


New Classification Scheme Validated for Patients With Acute Decompensated Heart Failure
Feb. 2, 2005 — A newly identified, validated classification scheme for patients with acute decompensated heart failure (ADHF) uses admission blood urea nitrogen (BUN), creatinine, and systolic blood pressure to assess risk of in-hospital mortality, according to the results of a study published in the Feb. 2 issue of JAMA.
http://www.medscape.com/viewarticle/498640?src=hp18.lead


Heart Failure Risk Doubled in Rheumatoid Arthritis
NEW YORK (Reuters Health) Feb 04 - Rheumatoid arthritis (RA) is associated with an elevated risk of congestive heart failure (CHF), according to a report in the February issue of Arthritis and Rheumatism. "This increased risk may be present at the earliest stages of the disease and may occur in the absence of overt CV risk factors or ischemic heart disease," the researchers report.
http://www.medscape.com/viewarticle/498793

[magdutz]

iata un articol care imi aminteste de cazul tipei aleia care a ramas insarcinata "prin impuscare" :)) ...sau, cum ar spune prietenul meu" there's a lot of sick people in this town"  :shock:

ORLANDO, FLA. -- An ovary that had been transplanted into a woman's forearm has undergone spontaneous ovulation followed by menstruation for approximately 10 months, Dr. Kutluk Oktay reported.

"Ovarian transplant to the forearm seems to be clinically useful to preserve ovarian function in patients facing radical surgery or cancer treatment," Dr. Oktay said at the annual meeting of the American Society for Reproductive Medicine.

This is the second ovarian transplant case reported by Dr. Oktay and his associates in which ovarian function resumed after the procedure. However, the first case required ovulation induction to get an oocyte for in vitro fertilization. In this case spontaneous ovulation and menstruation were observed, said Dr. Oktay of Cornell University, New York.

The 37-year-old patient has not attempted to get pregnant.

"The procedure was performed after the woman had undergone an oophorectomy of her remaining ovary because of a benign serous cyst.

Healthy tissue was harvested from the ovary, sliced into strips, and transplanted immediately to the medial aspect of her right forearm. A dosage of 75 of recombinant FSH was injected daily into the grafted tissue for 1 week, and 80 mg/day of aspirin was also given for 7 days to enhance vascularization. One week later, the patient was started on hormone replacement therapy, which was discontinued after 4 months.

At that time, ultrasound monitoring revealed follicular development, followed 2 weeks later menstruation. These By spontaneous monthly cycles have continued for at least 10 months.

In addition, the patient's menopausal symptons have resolved, and she has maintained normal, premenopausal hormone levels.

Dr. Oktay reported one factor that may have improved ovarian function in the second transplant: The ovarian tissue was placed in the inner forearm, and it received better blood flow than in the outer forearm, where it had been placed in the first case.

He says this site is also cosmetically more suitable, and the patient has reported no discomfort associated with ovulation.

[originaltup]

Nu inteleg: tie ti se pare ca ar fi o problema cu aceasta operatie?
Caci eu nu o vad, mai bine sa aiba femeia estrogenii ei personali decat sa-i faci substitutie hormonala.

PS. cred ca e evident de ce are nevoie in continuare de hormonii respectivi (la 37 ani adica)

[magdutz]

nu mi se pare ca ar fi o problema, mi se pare doar o idee....traznita :P ...am dat peste articolul asta cautand altceva pe net, si in acel context m-a amuzat teribil :)

[originaltup]

e din acelasi ciclu cu implantarea paratiroidelor (parca) in antebrat dupa o tiroidectomie (si mai sunt cateva exemple de genul asta)

[Qvadratus]

... mi se pare doar o idee....traznita  ...in acel context m-a amuzat teribil

Kum ar fi de ekzemplu si inplantarea testikolelor in antebrate.

[A CERB]

sau in faringe